Potential therapeutic target found to combat tuberculosis, a disrupted NAD(H) homeostasis

It has been uncertain how Mycobacterium tuberculosis deflects the immune response in humans, though evidence has pointed to host immunometabolism - the intrinsic link between metabolism in immune cells and their immune function. The pathogen M. tuberculosis is known to disrupt a metabolic pathway called glycolysis in infected myeloid cells, which include macrophages, through an unclear mechanism.

from Breaking World Pharma News https://ift.tt/LYo1iSa